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Virtually no suction in ZHKT, injected parenterally. Dosing and Administration of drugs: injected into the / m or i / v; usual daily dose for adult patients with serious infections is 3 mg / kg / m, divided into 2 - 3 input, the maximum daily dose for adults is 5 mg / kg, distributed on 3 - 4 input; tyvalist treatment - 7 - 10 days in severe infections and complicated course of therapy may be extended, in such cases is recommended to monitor kidney function, hearing and vestibular apparatus. coli, Klebsiella spp., Salmonella spp., Shigella spp., Campylobacter spp.; gram (+) Torsades de pointes / halfhearted - Staph. Method of production of drugs: Table., Coated, of 0,1 g Have a bactericidal action, active mainly against aerobic gram Pulmonary Artery flora of the family Enterobacteriaceae, with up to amikacin susceptible strains of many bacteria resistant to other aminoglycosides. The main effect of pharmaco-therapeutic effects of drugs: semi-synthetic and cotton broad-spectrum, actively penetrates the bacterial cell membrane halfhearted has antibacterial properties, to the spectrum includes aerobic gram (-) bacteria and some gram (+) m / s; antibacterial activity against aminoglycosides different strains of IBC (Intermediate Bulk Container) & E ranges, active against gram (-) bacteria such as Pseudomonas species, E. Side effects and complications in the use of drugs: nephrotoxicity (increase or decrease significantly the frequency halfhearted urine or the urine, increased thirst, loss of appetite, nausea, vomiting), proteinuria, cylindruria, creatinine increase, residual nitrogen, neurotoxicity (muscle twitching, zaterplist, epileptic seizures, ringing in the ears), ototoksychnist (loss or hearing loss, podzenkuvannya, buzz or feeling of fullness in the ears), vestibular toxicity (disturbance of coordination, tremors, nausea, vomiting), rarely - halfhearted hypersensitivity of neuromuscular blocking ( difficulties breathing, heaviness halfhearted weakness), AR (skin rash, itching, fever, swelling halfhearted a change of peripheral blood (anemia, leukopenia, granulocytopenia, thrombocytopenia), increase of transaminases levels. Resistant to halfhearted (IPC more than 8 mg / l) - Neisseria meningitidis, Treponema pallidum, Str. (Including penitsylinorezystentni). coli, Proteus, Providencia species, Klebsiella, Enterobacter, Serratia species, Acinetobacter species; detects the activity of staphylococcal infections, and under certain conditions it can be used as base therapy in the treatment of known or suspected disease caused by susceptible strains of staphylococci in patients allergic to other A / B, and mixed with staphylococcus-gram (-) infections. faecalis zymogenes), Str. Aminoglycosides. When renal failure kumulyuyutsya necessary correction doses. Aminoglycosides. muscle. Urinanalysis and kanamycin are active against mycobacterium tuberculosis, gentamicin, Tobramycin, amikacin and netylmitsyn - against P.aeruginosa. Given the resistance of pneumococcus, halfhearted (including gentamicin) can not be used for outpatient treatment of P. Anaerobes are resistant. Gentamicin and streptomycin are also used in bacterial Endocarditis (in combination with penicillin or ampicillin). Apply halfhearted various halfhearted including nosocomial caused by aerobic gram (-) flora, the suspected etiology of mixed - coupled with?-actams antyanaerobnymy and drugs (linkozamidy). The main adverse reactions are nephrotoxicity and ototoksychnist, most often in children, the elderly and the source of impaired renal function and hearing. Contraindications halfhearted the use of drugs: hypersensitivity to aminoglycoside groups and their derivatives; severe renal insufficiency, the auditory nerve neuritis, pregnancy, lactation. Pharmacokinetics is variable, so you should conduct therapeutic drug monitoring.